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MSRIT Downstream Process Technology & Bioseparation Techniques Sem 7
No Units Titles Sub Titles Chapters
1 Unit 1 Role of downstream processing in biotechnology Role and importance of downstream processing in biotechnological processes, Problems and requirements of bioproduct purification, Economics and downstream processing in Biotechnology, Cost cutting strategies, characteristics of biological mixtures, process design criteria for various classes of bioproducts (high volume, low value products and low volume, high value products), physicochemical basis of bio separation processes VIEW CHAPTERS
2 Unit 2 Primary separation and recovery process Cell disruption methods for intracellular products, removal of insolubles, biomass (and particulate debris) separation techniques, flocculation and sedimentation, centrifugation and filtration methods VIEW CHAPTERS
3 Unit 3 Enrichment operations Membrane  based separations (Micro- and Ultra-filtration) theory, design and configuration of membrane separation equipment, applications, precipitation methods with salts, organic solvents, and polymers, extractive separations, Aqueous two-phase extraction, supercritical extraction, In situ product removal/integrated bio processing VIEW CHAPTERS
4 Unit 4 Membrane science and technology Use of membrane diffusion as a tool for separating and characterizing naturally occurring polymers, solute polarization and cake formation in membrane ultra filtration  causes, consequences and control techniques, enzyme processing using ultra filtration membranes, separation by solvent membranes, ultra filtration and reverse osmosis VIEW CHAPTERS
5 Unit 5 Product resolution/fractionation Adsorptive chromatographic separation processes, electrophoretic separations (all electrophoresis techniques including capillary electrophoresis), hybrid separation technologies (membrane chromatography, electrochromotagraphy etc,), Gel Permeation Chromatography, Dialysis, Crystallization, HPLC and GC VIEW CHAPTERS
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